Rapid diastereocontrolled synthesis of 2,2,5-trisubstituted pyrrolidines.
نویسندگان
چکیده
2,2,5-Trisubstituted pyrrolidines are available from allylic pyroglutamates by Ireland-Claisen ester rearrangement followed by Eschenmoser sulfide contraction and reduction in a highly diastereoselective and efficient sequence. Some of the products from this sequence exhibit activity against S. aureus, but are much less active against E. coli.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 6 20 شماره
صفحات -
تاریخ انتشار 2008